Endocrine Abstracts

A longstanding unsettled question is whether pancreatic β-cells originate from exocrine duct cells. We have now used a genetic labeling approach to fate map embryonic and adult pancreatic duct cells. We employed a BAC genomic clone containing the Hnf1b locus to generate a transgenic mouse line that expresses a hormone-inducible form of Cre in pancreatic ducts. We verified that in this model Cre is specifically expressed throughout the pancreatic duct epithelium, in...